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Involved in the following projects during the 3rd programme

3rd Health Programme (2014-2020)
Managing Frailty. A comprehensive approach to promote a disability-free advanced age in Europe: the ADVANTAGE initiative [ADVANTAGE]
Managing Frailty. A comprehensive approach to promote a disability-free advanced age: the ADVANTAGE initiative
ADVANTAGE will build a common understanding on frailty to be used by Member States on...
Managing Frailty. A comprehensive approach to promote a disability-free advanced age: the ADVANTAGE initiative
ADVANTAGE will build a common understanding on frailty to be used by Member States on which to base a common management approach of older people who are frail or at risk for developing frailty in the European Union.
The identification of the core components of frailty and its management should promote the needed changes in the organization and the implementation of the Health and Social Systems to provide those models of care that, stemming from the particular health profile of each Member State (MS), will allow them to face the challenge of frailty within a common framework.
ADVANTAGE will summarise the current State of the Art for the different components of frailty and its management, both at individual and population level, will collect information on the development of programs to manage frailty in older adults in the EU and will propose, as its main outcome, a common European model to approach frailty. This model will include a road map that, considering the degree of frailty policies� development, will propose interventions for frail and at risk people and will establish tailored milestones for each MS in order to achieve a comprehensive approach to promote a disability-free advanced age. Furthermore, the model will identify gaps of knowledge in the field that would benefit from further research.
Start date: 01/01/2017 - End date: 31/12/2019
Keywords : [ Ageing ] [ Frailty ] [ Function ]

Call: Health Programme Adhoc Call for invited (named) beneficiaries
Topic: Prevention of frailty
3rd Health Programme (2014-2020)
ERN in Transplantation in Children (SOT HSCT) [ERN TRANSPLANTChild]
The paediatric transplantation (of solid organs and hematopoietic progenitors) has increased survival in children with end-stage disease, becoming one of the main treatment options for this population...
The paediatric transplantation (of solid organs and hematopoietic progenitors) has increased survival in children with end-stage disease, becoming one of the main treatment options for this population. However, there are significant challenges associated with optimising the effects of these interventions:
i)The mechanisms associated with tolerance to graft rejection;
ii) The pre-transplant -and surgical techniques and care procedures; ii) post-transplantation care;
iii) The specificities associated with this population group and type of disease;
iv) The social and economic impact of these surgeries on patients, their families and health systems.
Since these factors are key to the success of the process and a common link in various types of transplantations, there is a need to implement and standardise recent improvements in this field for routine use, directing them towards prevention, improvement of the surgical procedures themselves, treatment of chronicity and the appearance of secondary diseases associated with transplantation.
As a result of these activities, the paediatric transplantation network will achieve to increase life expectancy and quality of life of paediatric patients requiring a solid organ or hematopoietic progenitor transplantation and their families, and will provide added value,
Start date: 01/03/2017 - End date: 28/02/2018

Call: EUROPEAN REFERENCE NETWORKS SPECIFIC GRANT AGREEMENTS COVERING YEAR 2017
Topic: ERN Specific Grant Agreements Year 1
3rd Health Programme (2014-2020)
SGA 2nd Yr ERN TransplantChild [ERN TransplantChild]
Second Annual work Program for the ERN TransplantChild - Transplantation in Children, both Solid Organ Transplantation and HSCT
TransplantChild is one of the ERNs approved by the European Commission. ...
Second Annual work Program for the ERN TransplantChild - Transplantation in Children, both Solid Organ Transplantation and HSCT
TransplantChild is one of the ERNs approved by the European Commission.
Transplanted children generates a lifelong chronic condition or `disease´, mostly imposed by the immunosuppression.
The new lifelong medical condition is common in many aspects to all transplanted children.
TransplantChild applies a multi-disciplinary and patient-centered approach, identifying common areas of clinical and therapeutic innovation with the widest possible applicability
Without leaving aside other more specific aspects of each type of transplant
Improving areas:
- Improvement of the prevention mechanisms as well as surgical, preparative, care procedures and other technical issues.
- Prevention of complications and secondary diseases related to transplantation.
- The mechanisms associated with graft tolerance vs rejection.
- Psychosocial care, education and other aspects related to quality of life.
- Adulthood transition.
- The impact on social and sustainability issues of these processes;
- The patients and families’ empowerment.
Start date: 01/03/2018 - End date: 28/02/2019

Call: EUROPEAN REFERENCE NETWORKS SPECIFIC GRANT AGREEMENTS COVERING YEAR 2018
Topic: ERN Specific Grant Agreements Year 2
3rd Health Programme (2014-2020)
3rd to 5th annual work program ERN TransplantChild [ERN TransplantChild]
3rd - 5th Annual Work Program for the ERN TransplantChild - Transplantation in Children, both Solid Organ Transplantation
and HSCT
Description of activities planned for the developement by the coordi...
3rd - 5th Annual Work Program for the ERN TransplantChild - Transplantation in Children, both Solid Organ Transplantation
and HSCT
Description of activities planned for the developement by the coordination of the third to fifth year of the ERN TransplantChild. 18 Health Care Providers from 11 different European countries
The general objectives are:
A. The identification of key aspects for the complete development of the Network and the development of actions for the joint achievement of the Network objectives:
B. The support and coordination of the Network activities.

The outputs we plan to obtain are related to report and analysis of key aspects related to paediatric transplantation, with a great impact in patients, families and professionals involved in the care of this patients.
Start date: 01/03/2019 - End date: 28/02/2022

Call: Multiannual Grant Agreements for European Reference Networks
Topic: ERN Specific Grant Agreements 2019 - 2021
3rd Health Programme (2014-2020)
FRAILTOOLS: A comprehensive validation of tools to screen and diagnose frailty in different clinical and social settings to provide instruments for integrated care in older adults [FRAILTOOLS]
There is a proved strong evidence of the usefulness of frailty as a predictive factor of relevant undesired outcomes in populations of older adults. Several studies have been published showing the uti...
There is a proved strong evidence of the usefulness of frailty as a predictive factor of relevant undesired outcomes in populations of older adults. Several studies have been published showing the utility of the concept in improving the prognostic accuracy and the prediction of different risks (hospitalization, surgical and non-surgical complications, length of stay, death, incident disability, etc) in emergency departments, cardiac surgery, surgical patients and in patients with cardiovascular disease. These studies have placed the focus in assessing population risk, while the validation process for these instruments as diagnostic or screening tools has been usually neglected.FRAILTOOLS aims to assess the usefulness as screening and diagnosis tools of some selected instruments to detect frailty in both clinical (Hospital and Primary Care) and social (nursing homes) settings, providing diagnostic algorithms clinically sound. Target groups are all of those older adults at risk for frailty (pre-frail) plus those that are frail and are at risk for developing disability. According to the published prevalence of these two conditions, the target population concerned by this project represent around 40-50% of older people older than 65 and 60-70% of people older than 75. Once determined the best tools of screening and diagnosis in different settings of care, we will reach conclusions for this people wherever the level of care they need and currently use. The benefit will expand to the Health Systems and Social Care as it will provide validated instruments that are necessary to provide an appropriate care for older adults by means of a comprehensive, continued, coordinated and integrated care.FRAILTOOLS consortium involves 6 of the most renowned partners in research on ageing and frailty from Spain, UK, Italy, France and Poland, plus the support of a number of highly relevant collaborating stakeholders fully committed with the project.
Start date: 01/05/2015 - End date: 31/12/2018

Call: Call for Proposals for Projects 2014
Topic: Adherence, frailty, integrated care and multi-chronic conditions
3rd Health Programme (2014-2020)
PaEdiatric Transplantation European Registry [PETER]
Paediatric transplantation has dramatically changed the life expectancy of many children by providing treatment for organ failure who would otherwise have not survived. European Reference Networks (...
Paediatric transplantation has dramatically changed the life expectancy of many children by providing treatment for organ failure who would otherwise have not survived. European Reference Networks (ERN) for rare diseases should serve as research and knowledge centres, updating and contributing to the latest scientific findings, treating patients from Member States and ensuring the availability of subsequent treatment facilities where necessary. ERN TransplantChild is focussed on both paediatric Solid Organ Transplantation (SOT) and Hematopoietic Stem Cell Transplantation (HSCT). Both SOT and HSCT are low-prevalence and complex conditions that require highly specialised expertise and resources. Current approaches are insufficient to fully address long-term graft and patient survival while providing the best possible QoL. The overall objective of the project is to create PETER, a new rational, efficient, interoperable, open, accessible paediatric transplant registry for all type of paediatric transplantation that allows generating real-world evidence monitoring by the identification of common outcomes for all types of transplant, and which can be used as a model to support care and research for the benefit of patients, improvement of the transplanted patient healthcare, their life expectancy and long-term quality of life of children and their families. Peter will lean on an interoperable technology platform with a module of business intelligence that will allow it to be a predictive registry directly impacting on the (a) process of patient care, improving the process of personalised clinical decision-making in the healthcare systems. PETER shall be built with the support and according to the standards set up by the European Platform on Rare Diseases Registration (EU RD Platform).
Start date: 01/07/2020 - End date: 30/06/2023

Call: Call for Proposals for Projects 2019
Topic: Rare disease registries for the European Reference Networks (Heading 2.1 of the AWP 2019)
3rd Health Programme (2014-2020)
European Joint Action on antimicrobial resistance and associated infections [EU-JAMRAI]
Antimicrobial resistance (AMR) is a serious public health threat that is gaining swift ground. The increase of multi-resistant bacteria associated to the lack of new antibiotics represents a threat to...
Antimicrobial resistance (AMR) is a serious public health threat that is gaining swift ground. The increase of multi-resistant bacteria associated to the lack of new antibiotics represents a threat to global health. Some patients are faced with no therapeutic solutions as some bacteria resist to all antibiotics. Moreover, “old” antibiotics and to some extent more “recent” ones are gradually removed from the market because they are not economically sustainable, albeit being still possibly efficient. The issue of antimicrobial resistance is a real challenge that decision-makers are well aware of and has gained a high priority among public health challenges.
A closely related challenge is the issue of Healthcare Associated Infections that shall not be considered separately. In fact, infection prevention and control strategies should go hand in hand with i) prudent use of antibiotics ii) appropriate tools for monitoring and surveillance and iii) accurate diagnostic tests to decide on the right therapy.
The various national, European and international initiatives that have emerged over the last decade have shown a great commitment to actively tackle these issues.It is essential that all actors in the field of AMR join forces so as to avoid duplication of efforts and ensure greater coherence. Moreover, it is essential that the strategies adopted extend beyond the sole human health domain and bring a global One Health response.
The overall objective of the AMR-HCAI JA is to ensure that policies for control of AMR and HCAI are adopted and implemented across EU MS in a coordinated way, ensuring national specificities are accounted for, in line with the ECDC and WHO guidelines and recommendations, and in conjunction with other European initiatives.This will be made possible by bringing together different networks of policy makers, experts and organizations on AMR and HCAI working in different European and International initiatives and projects relevant for policy decision.
Start date: 01/09/2017 - End date: 28/02/2021

Call: Joint Actions 2016
Topic: Antimicrobial resistance and Health Care Associated Infections
3rd Health Programme (2014-2020)
ERN TRANSPLANTATION IN CHILDREN (SOT&HSTC) [ERN TRANSPLANT-CHILD]
ERNs should link existing highly specialised healthcare providers, as expertise in rare or lowprevalence
complex disease or conditions is scarce and dispersed. ERNs will facilitate timely access
to ...
ERNs should link existing highly specialised healthcare providers, as expertise in rare or lowprevalence
complex disease or conditions is scarce and dispersed. ERNs will facilitate timely access
to care by centralising knowledge and experience, research and training for these diseases and
conditions. We propose TRANSplantCHILD based on the understanding of transplantation in children as
a low-prevalence complex medical condition that requires highly specialised expertise and
resources.
Paediatric transplantation (PT), both solid organ (SOT) and hematopoietic stem cell transplantation
(HSCT), is the only curative procedure for several rare diseases causing the highest mortality rate in
European children. Paediatric surgical procedures allow transplantation of virtually all organs, but a
clear gap yet exists, as proper post-transplant care constitutes a challenge that demands the
multidisciplinary coordinated efforts of organ-focused specialists, especially when more than one
organ is transplanted, with other specialised clinical and laboratory resources that support the
transplantation procedure in common processes for SOT and HSCT as immunosuppression,
immune reconstitution, rejection, tolerance, risk of infection, second malignancies, etc.
In addition, other areas of non-medical supportive care need to be in place for children and their
families, due to severe psychological and socio-economic issues that extend to adulthood. Costeffective
measures will clearly be beneficial in PT when compared to those obtained in adults as life
expectancy after transplantation is much longer.
Transplanted individuals shift their primary disease to a chronic condition of immunosuppresion to
avoid rejection, requiring proper monitoring and care of post-transplant complications. This state is
even more life-conditioning for children, demanding even more expertise in reference centres
connecting multidisciplinary medical expertise, transfer of knowledge and innovative medicine as
children
Start date: 15/03/2017 - End date: 14/03/2022

Call: European Reference Networks
Topic: ERN-2016 - European Reference Networks – Framework Partnership Agreement