Objectives Recent outbreaks of vaccine preventable diseases have brought to light important gaps in immunization coverage in Europe. Specific population groups have not had sufficient access to vaccines due to socioeconomic, cultural, geographic or health reasons. Activities The Innovative Immunisation Hubs (‘ImmuHubs’) project will 1) Establish proactive partnerships with citizen groups, public health agencies, key stakeholders and the general public to improve access to vaccination in disadvantaged, isolated, and difficult to reach population groups in 8 European countries, according to best practices for community partnerships. 2) Create innovative immunisation actions, which will increase vaccine uptake across borders, generations and population groups. 3) Develop sustainable solutions for vaccine protection of EU citizens, including during and after the COVID pandemic. Type and number of persons benefiting from the project Cyprus, Greece, Finland, Portugal, Poland, and Serbia, will each be hosting 3 ImmuHubs representing 1) disenfranchised populations 2) isolated/closed communities and 3) ethnic/cross-border populations. Two additional ImmuHubs will engage populations with health risks. A set of digital/analogue tools will be deployed to measure the impact of actions taken. Expected results 10% increase in the uptake of childhood and life-course vaccines >75% accuracy in awareness of the immunisation status 80% accurate understanding of vaccination needs specific to the population group 20% increase in planned consultations with health mediators and professionals 20% increase in intergenerational vaccine communication in the household/family unit Type and number of outputs to be produced The 3-year project will generate 24 deliverables dedicated to: management (4), dissemination activities (4), evaluation and COVID-aspects (4), ImmuHubs (4), health literacy in families/risk groups (4), systematic check-ups/analysis/sustainability (4).